Description
Our SS-31 50mg vial holds 50mg of lyophilized SS-31, a mitochondria-targeted tetrapeptide, made and tested in the USA. It’s for in-vitro and lab research only.
On older labels you may see this listed simply as 31. It’s the same peptide, SS-31.
SS-31 at a glance
SS-31, also called elamipretide, is a four-amino-acid peptide: D-Arg-Dmt-Lys-Phe-NH2. It alternates positive charges with aromatic rings, a design that lets it slip through cell membranes and collect in mitochondria.
Once there, it binds cardiolipin, a fat that’s found almost only in the inner mitochondrial membrane and that holds the energy-making machinery in place.
SS-31 mechanism of action
Cardiolipin holds together the protein complexes that make ATP in mitochondria. When it’s oxidized, those complexes work less well and leak more free radicals.
SS-31 binds cardiolipin and protects it, which in lab studies kept the electron transport chain working more efficiently and cut oxidative damage. It doesn’t depend on the membrane voltage to get into mitochondria, which sets it apart from other targeted antioxidants.
SS-31 50mg specifications
- Compound: SS-31
- CAS number: 736992-21-5
- Molecular formula: C32H49N9O5
- Molar mass: 639.8 g/mol
- Sequence: D-Arg-Dmt-Lys-Phe-NH2
- Amount: 50mg per vial
- Form: lyophilized (freeze-dried) powder
- Vial size: 5mL glass vial
- Purity: 99% or higher by HPLC
- Made in: USA
- SKU: CP-SS31-50
- Use: laboratory research only
What the research says about SS-31
Hazel Szeto and Peter Schiller designed it in the early 2000s; SS stands for Szeto-Schiller. Stealth BioTherapeutics took it into clinical trials for mitochondrial diseases, including primary mitochondrial myopathy and Barth syndrome.
It’s one of the few mitochondria-targeted peptides with real human trial data. This vial is research material, not the clinical product.
The primary literature is on PubMed. Here’s a search for SS-31 studies to start from.
SS-31 compared with similar compounds
SS-31 50mg is easier to place once you see it next to the compounds it’s usually compared with. SS-31 targets cardiolipin on the inner mitochondrial membrane. The others:
- Epithalon is the tetrapeptide Ala-Glu-Asp-Gly, studied for telomerase activity
- NAD+ is the coenzyme behind cell energy and sirtuin activity, whose levels fall with age
- Glutathione is the cell’s main antioxidant tripeptide
- MOTS-c is a 16-amino-acid peptide coded in mitochondrial DNA, studied for glucose use in muscle
- GHK-Cu is the copper-binding tripeptide studied for collagen and skin repair
Aging research splits into a few processes, and each of these compounds targets one: telomeres, cell energy, mitochondria, oxidative stress or tissue repair. See them all on our anti-aging peptides page.
How to reconstitute SS-31 50mg
Concentration is the amount in the vial divided by the volume of water you add. With 50mg of powder in this vial:
- 2mL of bacteriostatic water gives 25mg/mL
- 3mL of bacteriostatic water gives 16.67mg/mL
- 5mL of bacteriostatic water gives 10mg/mL
Go with whichever number is easiest to work with in your protocol, and label the vial with the concentration and the date you mixed it. The vial itself holds 5mL, so that’s the upper limit.
Use sterile bacteriostatic water, like our 10mL bacteriostatic water. Let the vial reach room temperature, run the water slowly down the inside of the glass, then roll the vial gently until the powder dissolves. Don’t shake it. Shaking can shear peptide chains.
SS-31 50mg storage and shelf life
The dry powder keeps best cold. A freezer at -20°C is ideal for long-term storage, and a fridge works for a few weeks. After reconstitution, store it in the fridge and finish it within roughly four weeks.
If you keep several vials going at once, our 10 vial container keeps them upright and together on a fridge shelf, and spare 3mL vial caps protect the stoppers once the seals are off.
SS-31 50mg purity and lab testing
SS-31 50mg is made in the USA, and every batch goes to an independent U.S. laboratory before it’s sold. The lab confirms identity, measures the content and checks purity by HPLC. Our standard is 99% or higher.
Scroll through the photos at the top of the page and you’ll find the current batch’s certificate of analysis. We post the actual report, so you can check the figures yourself.
Purity isn’t the whole story, so batches are screened for endotoxins, heavy metals and sterility too. Write the batch number from the label into your notes so you can match results to the paperwork later.
SS-31 sizes compared
- SS-31 10mg: $59.00, about $5.90 per mg
- SS-31 30mg: $160.00, about $5.33 per mg
- SS-31 50mg (this page): $180.00, about $3.60 per mg
SS-31 50mg is one of the larger sizes, and bigger vials cost less per milligram. It suits longer studies where you’d otherwise reorder.
Related to SS-31 50mg
- ATX-304 Capsules 100mg (60 Count), an oral capsule format
- 5-Amino-1MQ 10mg, an NNMT inhibitor
- Glutathione 1500mg, an antioxidant tripeptide
- Methylcobalamin B12 10mg/mL (10mL), a ready-made 10mL liquid
- NAD+ 500mg, a coenzyme
Browse the full anti-aging peptides range, or see every vial on our research peptides page.
Common questions about SS-31 50mg
How much is in the SS-31 50mg vial?
50mg of freeze-dried powder. The amount is printed on the label.
Is there a certificate of analysis for SS-31 50mg?
Yes. The current batch’s COA is in the image gallery on this page.
What do I mix SS-31 50mg with?
Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.
How should I store it?
Keep sealed vials in the freezer for long-term storage or the fridge for a few weeks. Once mixed, refrigerate and use within about 28 days.
Can SS-31 be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
Buy SS-31 50mg online
Order SS-31 50mg now for $180.00, down from $218.00. It’s in stock, and checkout takes about two minutes. Need water to mix it? Add a 10mL bacteriostatic water to the same order.
Need more for the same project? See the rest of our anti-aging peptides.
For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.
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