Description
MOTS-c 10mg is a 10mg vial of MOTS-c, a mitochondrial-derived peptide, made in the USA and supplied as freeze-dried powder. It’s for in-vitro and lab research only.
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA gene. It was described in 2015 by Pinchas Cohen’s group at USC.
It acts on metabolism, in part through AMPK.
MOTS-c mechanism of action
Most proteins are coded in the cell nucleus. MOTS-c is one of a handful of peptides coded in mitochondrial DNA instead. Its main target looks like the folate cycle, which feeds into AMPK activation and better glucose handling in muscle.
Under stress it can move into the nucleus and change gene expression. Circulating levels drop with age in both mice and people, which is why it’s studied in metabolism and aging.
MOTS-c 10mg product details
- Compound: MOTS-c
- CAS number: 1627580-64-6
- Molecular formula: C101H152N28O22S2
- Molar mass: 2,174.6 g/mol
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Amount: 10mg per vial
- Form: lyophilized (freeze-dried) powder
- Vial size: 3mL glass vial
- Purity: 99% or higher by HPLC
- Made in: USA
- SKU: CP-MOTSC-10
- Use: laboratory research only
Published MOTS-c studies
Lee and colleagues reported in Cell Metabolism (2015) that MOTS-c prevented diet-induced obesity and insulin resistance in mice.
Reynolds and colleagues showed in 2021 that it improved physical capacity in young, middle-aged and old mice.
To read the papers yourself, start with this PubMed search for MOTS-c.
How MOTS-c compares
Here’s how MOTS-c 10mg fits among related compounds. MOTS-c is a 16-amino-acid peptide coded in mitochondrial DNA, studied for glucose use in muscle. By comparison:
- AOD-9604 is hGH fragment 177-191 with an extra tyrosine, studied for fat breakdown without raising IGF-1
- HGH Fragment 176-191 is the 16-residue C-terminal end of growth hormone, the parent of AOD-9604
- 5-Amino-1MQ is a small molecule that blocks the enzyme NNMT inside fat cells
These four are studied for fat metabolism but act in very different places: the growth hormone fragments on fat tissue from outside, 5-Amino-1MQ and MOTS-c from inside the cell. See them all on our weight loss peptides page.
Lab-tested MOTS-c 10mg
We only sell U.S.-made products, and MOTS-c 10mg is no exception. Each batch is tested by an outside U.S. lab for identity, content and purity, with a 99%+ HPLC purity standard.
The certificate of analysis for the batch in stock is posted in the product gallery above. Click through the images and you’ll see the lab report with its date and numbers.
Batches are also screened for endotoxins, heavy metals and sterility. Those contaminant checks matter as much as purity for cell work, where a small amount of endotoxin can skew results.
Reconstituting MOTS-c 10mg
Concentration is the amount in the vial divided by the volume of water you add. With 10mg of powder in this vial:
- 1mL of bacteriostatic water gives 10mg/mL
- 2mL of bacteriostatic water gives 5mg/mL
- 3mL of bacteriostatic water gives 3.33mg/mL
Choose the volume that suits your measurements. Mark the vial with the concentration and date so nobody has to guess later. The vial itself holds 3mL, so that’s the upper limit.
Bacteriostatic water is the usual choice. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking can shear peptide chains. Skip it.
MOTS-c 10mg storage and shelf life
Store sealed vials of MOTS-c 10mg in the freezer (-20°C) or the fridge (2 to 8°C), out of direct light. Mixed solution goes back in the fridge and should be used within about 28 days.
A 6 vial container keeps open and sealed vials upright and apart, which makes the fridge a lot easier to manage. For a bigger collection, the Big Everything Box holds vials and supplies in one latching case.
Other MOTS-c strengths
- MOTS-c 10mg (this page): $58.00, about $5.80 per mg
- MOTS-c 20mg: $90.00, about $4.50 per mg
- MOTS-c 40mg: $160.00, about $4.00 per mg
MOTS-c 10mg is the entry size, handy when you only need a little or want to try MOTS-c before committing to a bigger vial.
Often ordered with MOTS-c 10mg
- SLU-PP-332 BAM-15 Capsules 250mcg/50mcg (60 Count), an oral capsule format
- GLP3-R 10mg, a triple agonist
- Lipo-Mino-Mix 244.4mg/mL (10mL), a ready-made 10mL liquid
- SLU-PP-332 10mg, an ERR agonist
- GLP2-T 60mg, a GIP/GLP-1 agonist
Browse the full weight loss peptides and anti-aging peptides range, or see every vial on our research peptides page.
MOTS-c 10mg questions
How much is in the MOTS-c 10mg vial?
10mg of freeze-dried powder. The amount is printed on the label.
Is there a certificate of analysis for MOTS-c 10mg?
Yes. The current batch’s COA is in the image gallery on this page.
What do I mix MOTS-c 10mg with?
Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.
How should I store it?
Keep sealed vials in the freezer for long-term storage or the fridge for a few weeks. Once mixed, refrigerate and use within about 28 days.
Can MOTS-c be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
Buy MOTS-c 10mg from Certified Peptides
This vial is in stock at $58.00. Add it to the cart and check out in a couple of minutes.
Need more for the same project? See the rest of our weight loss peptides and anti-aging peptides.
For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.
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