Description
Adipotide 10mg is a 10mg vial of Adipotide, a peptide-drug conjugate that targets fat tissue blood vessels, made in the USA and supplied as freeze-dried powder. It’s intended for lab research only.
Adipotide at a glance
Adipotide is a synthetic peptide with two parts. One end, CKGGRAKDC, homes in on prohibitin, a protein found on the blood vessels that supply white fat. The other end, D(KLAKLAK)2, is a membrane-disrupting sequence that kills the cells it reaches.
It was developed at the University of Texas MD Anderson Cancer Center by Wadih Arap, Renata Pasqualini and Mikhail Kolonin. It isn’t an approved drug.
How Adipotide acts in the lab
The targeting end binds prohibitin on endothelial cells lining the vessels of white fat. Once the conjugate is pulled into those cells, the KLAKLAK end damages mitochondrial membranes and triggers cell death.
With its blood supply cut, the fat tissue shrinks. Labs studying it watch kidney markers closely, since the kidney effects were the main problem in the primate work.
Adipotide 10mg technical data
- Compound: Adipotide
- Also known as: FTPP, prohibitin-targeting peptide
- Molecular formula: C111H206N36O28S2
- Molar mass: 2,557.2 g/mol
- Structure: CKGGRAKDC-GG-D(KLAKLAK)2
- Amount: 10mg per vial
- Form: lyophilized (freeze-dried) powder
- Vial size: 3mL glass vial
- Purity: 99% or higher by HPLC
- Made in: USA
- SKU: CP-ADIPO-10
- Use: laboratory research only
Published Adipotide studies
Kolonin and colleagues reported in Nature Medicine in 2004 that the peptide reversed obesity in mice by cutting off the blood supply to fat tissue.
In 2011, Barnhart and colleagues tested it in obese rhesus monkeys (Science Translational Medicine). The animals lost about 11% of body weight in four weeks, with signs of reversible kidney stress.
The primary literature is on PubMed. Here’s a search for Adipotide studies to start from.
Adipotide 10mg purity and lab testing
We only sell U.S.-made products, and Adipotide 10mg is no exception. Each batch is tested by an outside U.S. lab for identity, content and purity, with a 99%+ HPLC purity standard.
The certificate of analysis for the batch in stock is posted in the product gallery above. Click through the images and you’ll see the lab report with its date and numbers.
On top of purity, each batch is screened for endotoxins, heavy metals and sterility. For cell culture work that screen is often the more important number.
How to reconstitute Adipotide 10mg
Concentration is the amount in the vial divided by the volume of water you add. With 10mg of powder in this vial:
- 1mL of bacteriostatic water gives 10mg/mL
- 2mL of bacteriostatic water gives 5mg/mL
- 3mL of bacteriostatic water gives 3.33mg/mL
Choose the volume that suits your measurements. Mark the vial with the concentration and date so nobody has to guess later. The vial itself holds 3mL, so that’s the upper limit.
Bacteriostatic water is the usual choice. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking can shear peptide chains. Skip it.
Adipotide 10mg storage and shelf life
Store sealed vials of Adipotide 10mg in the freezer (-20°C) or the fridge (2 to 8°C), out of direct light. Mixed solution goes back in the fridge and should be used within about 28 days.
A 6 vial container keeps open and sealed vials upright and apart, which makes the fridge a lot easier to manage. For a bigger collection, the Big Everything Box holds vials and supplies in one latching case.
Planning a study with Adipotide 10mg
Start from the protocol. Total the amount every arm needs from the first time point to the last, divide by the 10mg in a vial and add a spare. It’s cheaper to order once than to wait on a second shipment halfway through.
Mix one vial at a time and keep the rest sealed in the freezer. Dry powder keeps far longer than solution, so there’s no reason to reconstitute everything at the start.
Keep vials from one batch together in a study where you can. The batch number on the label ties each result back to its certificate of analysis.
Related to Adipotide 10mg
- SLU-PP-332 BAM-15 Capsules 250mcg/50mcg (60 Count), an oral capsule format
- GLP1-S 10mg, a GLP-1 agonist
- SLU-PP-332 Capsules 300mcg (100 Count), an oral capsule format
- 5-Amino-1MQ 10mg, an NNMT inhibitor
- ATX-304 Capsules 100mg (60 Count), an oral capsule format
Browse the full weight loss peptides range, or see every vial on our research peptides page.
Adipotide 10mg FAQ
How much is in the Adipotide 10mg vial?
10mg of freeze-dried powder. The amount is printed on the label.
Is there a certificate of analysis for Adipotide 10mg?
Yes. The current batch’s COA is in the image gallery on this page.
What do I mix Adipotide 10mg with?
Sterile bacteriostatic water is the usual choice. The reconstitution section above shows the concentration for each volume.
How should I store it?
Keep sealed vials in the freezer for long-term storage or the fridge for a few weeks. Once mixed, refrigerate and use within about 28 days.
Can Adipotide be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
Buy Adipotide 10mg online
Order Adipotide 10mg now for $165.00. It’s in stock, and checkout takes about two minutes.
Need more for the same project? See the rest of our weight loss peptides.
For laboratory research use only. Not for human or veterinary use. These statements have not been evaluated by the FDA.
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